Aims & Goals

The aim of ULTRACHIRAL is to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the “holy-grail” of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical, medical, and chemical analysis industries; (3) analysis of chirality in bodily fluids as a diagnostic tool in medicine, drug metabolism and pharmacokinetics; (4) the measurement of the chirality of single molecules, by adapting CCP to microresonators, which have already demonstrated single-molecule detection; and (5) real-time chiral monitoring of terpene emissions from individual trees and forests, as a probe of forest ecology (e.g. detecting parasite infestation).

To this end, we have created a consortium, bringing together experts from the fields of

  • Whispering Gallery Mode Micro-resonators
    • which have already demonstrated single-molecule detection capabilities
  • Plasmonics & Metamaterials
    • which can be used to enhance chiral signals
  • Medical research
    • with experience in the role of chiral molecules in human biology
  • Environmental science
    • performing field studies of chiral emissions in ecosystems such as the Amazon rain forest
  • State-of-the-Art optical detectors (SME)
    • which provide with specialized detectors used throughout the project